Innovation is a vital practice in the knowledge economy. Also vital is finding ways to scale innovations so that they can have significant impact. The Open African Innovation Research (Open AIR) network has collected data in numerous African innovation settings over the past decade, and has, in the process, developed a four-pillar taxonomy of scaling practices. As outlined in its 2020 Scaling Innovation report, which draws on findings from 10 African countries, Open AIR has found that scaling by the continent’s knowledge-based enterprises can best be understood in terms of four overlapping dimensions: expanding coverage; broadening activities; changing behaviour; and building sustainability.